Standardizing design performance comparison in microfluidic manufacturing

Microfluidic devices published in literature today lack sufficient information for automating the physical design process. Moreover, the constantly changing landscape of manufacturing and technological requirements poses a large problem in the physical design automation space. In this talk, we discuss some of the methodologies and standards formulated by CIDAR at BU and CARES at UC Riverside that allow not only allow the researchers in the physical design automation space to share and compare their results but also provide means for capturing the Specify, Design and Build lifecycle in microfluidic design

Shaping the cellular landscape with Set2/SETD2 methylation

Chromatin structure is a major barrier to gene transcription that must be disrupted and re-set during each round of transcription. Central to this process is the Set2/SETD2 methyltransferase that mediates co-transcriptional methylation to histone H3 at lysine 36 (H3K36me). Studies reveal that H3K36me not only prevents inappropriate transcriptional initiation from arising within gene bodies, but that it has other conserved functions that include the repair of damaged DNA and regulation of pre-mRNA splicing. Consistent with the importance of Set2/SETD2 in chromatin biology, mutations of SETD2, or mutations at or near H3K36 in H3.3, have recently been found to underlie cancer development. This review will summarize the latest insights into the functions of Set2/SETD2 in genome regulation and cancer development

Benefits and Risks of Big Data

Big data is one of the most prevalent topics in information systems today. The purpose of this paper is to explore big data, its past uses, legal history, current and potential security risks, and potential future uses. This literature review primarily focuses on the benefits of big data as well as the risks associated with big data. The research provides a general overview of big data and some of the technologies related to big data. The authors conclude with suggestions for future research of big data

Moodys Town Hall Meeting transcript

Other unidentified stakeholders participated in the Moody\u27s Town Hall discussion as wel

Characterization of Ion Cyclotron Resonance Acceleration for Electric Propulsion with Interferometery

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90620/1/AIAA-48087-936.pd

Measurements on NASA Langley Durable Combustor Rig by TDLAT: Preliminary Results

Detailed knowledge of the internal structure of high-enthalpy flows can provide valuable insight to the performance of scramjet combustors. Tunable Diode Laser Absorption Spectroscopy (TDLAS) is often employed to measure temperature and species concentration. However, TDLAS is a path-integrated line-of-sight (LOS) measurement, and thus does not produce spatially resolved distributions. Tunable Diode Laser Absorption Tomography (TDLAT) is a non-intrusive measurement technique for determining two-dimensional spatially resolved distributions of temperature and species concentration in high enthalpy flows. TDLAT combines TDLAS with tomographic image reconstruction. Several separate line-of-sight TDLAS measurements are analyzed in order to produce highly resolved temperature and species concentration distributions. Measurements have been collected at the University of Virginia's Supersonic Combustion Facility (UVaSCF) as well as at the NASA Langley Direct-Connect Supersonic Combustion Test Facility (DCSCTF). Measurements collected at the DCSCTF required significant modifications to system hardware and software designs due to its larger measurement area and shorter test duration. Initial LOS measurements from the NASA Langley DCSCTF operating at an equivalence ratio of 0.5 are presented. Results show the capability of TDLAT to adapt to several experimental setups and test parameters